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US 10,899,695 B2Granted
Process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes
AssigneeIdorsia Pharmaceuticals Ltd
InventorsLee McLaren, Daniel To, David Tovell, Stefan Abele
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Abstract
The present invention relates to a process for the manufacturing of 1-aryl-1-trifluoromethylcyclopropanes, which serve as intermediates for the manufacturing of calcium T channel blockers of the general formula (A) which are described in WO 2015/186056.
Claims17
A process, comprising:
- the reaction of a compound of formula (II)
- with SF4 and HF, to give a compound of formula (III)
- wherein R1 is H or Br.
A process for the manufacturing of the compound of formula (III)
- said process comprising the reaction of a compound of formula (II)
- wherein R1 is H or Br, with SF4 and HF.
A compound of formula (Va)
- wherein each R2 is methyl, ethyl, isopropyl, n-butyl, benzyl or H, or a salt of said compound.
Dependencies are inferred from the claim text.