Drug disposal devices and methods of use
OwnerKirti H. Valiainventor
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Abstract
Drug disposal devices and systems for reducing the amount of drug contained in a transdermal drug delivery patch are disclosed. The drug disposal devices contain an adsorbing substance, such as activated carbon, and are capable of adsorbing residual drug from the transdermal patch and preventing back-extraction of the drug. Also disclosed are methods of manufacturing the drug disposal devices and methods of using the drug disposal devices for reducing the amount of drug contained within a transdermal drug delivery patch.
Claims20
A drug disposal device for reducing an amount of drug contained in a transdermal patch, the drug disposal device comprising:
- (a) an adsorbing layer having a first surface and a second surface, wherein the adsorbing layer comprises a hydrogel, and wherein the hydrogel is a homogeneous mixture of gel components comprising;
- (i) at least about 5% by weight activated carbon;
- (ii) a binding agent;
- and
- (iii) one or more polyols selected from the group consisting of glycerol, polyethylene glycol and a combination of glycerol and polyethylene glycol;
- (b) a release liner disposed on the first surface of the adsorbing layer;
- and
- (c) a backing film disposed on the second surface of the adsorbing layer.
A method for reducing the amount of drug contained in a transdermal patch, the method comprising:
- (a) providing a drug disposal device comprising:
- (i) an adsorbing layer having a first surface and a second surface, wherein the adsorbing layer comprises a homogeneous hydrogel having a thickness in the range from about 15 mil to about 45 mil, the homogeneous hydrogel comprising:
- (A) at least about 10% by weight steam-activated carbon;
- (B) a thermoplastic polymer binding agent;
- and
- (C) a polyol selected from the group consisting of glycerol and polyethylene glycol;
- wherein the homogenous hydrogel is substantially free of air;
- (ii) a scrim substantially embedded in the hydrogel of the adsorbing layer;
- (ii) a release liner disposed on the first surface of the adsorbing layer;
- and
- (iii) a backing film disposed on the second surface of the adsorbing layer;
- (b) removing the release liner, whereby the first surface of the adsorbing layer is exposed;
- and
- (c) contacting a drug delivery layer of the transdermal patch with the first surface of the adsorbing layer, wherein the drug delivery layer comprises an amount of drug, and wherein the contact reduces the amount of drug in the delivery layer.
A method of manufacturing a drug disposal device, wherein the method comprises:
- (1) producing a homogenous hydrogel mixture by combining a set of ingredients, the ingredients comprising:
- (a) at least about 5% by weight activated carbon;
- (b) a binding agent;
- (c) glycerol or polyethylene glycol;
- and
- (d) a water component;
- (2) coating the homogenous hydrogel onto a release liner at a thickness of at least about 25 mil to about 35 mil to produce a homogenous hydrogel layer
- (3) disposing onto the homogenous hydrogel layer a scrim, wherein the scrim is substantially embedded into the homogenous hydrogel;
- (4) disposing onto the scrim and homogenous hydrogel layer a backing film;
- and
- (5) crosslinking the homogenous hydrogel layer.
Dependencies are inferred from the claim text.