Devices and methods for extracorporeal conditioning of blood

A device for extracorporeal conditioning of blood, comprising:

• a conditioning module comprising an external frame, an inlet cover, a fluid inlet disposed on the inlet cover, an outlet cover, and a fluid outlet disposed on the outlet cover, the conditioning module defining an internal chamber and a passageway extending between the fluid inlet and the fluid outlet;
• a first fiber assembly disposed within the internal chamber and having a first peripheral edge;
• potting material disposed throughout the first peripheral edge to create a circumferential seal that defines a flow path through the first fiber assembly that has a substantially circular cross-sectional shape, the flow path comprising a portion of the passageway;
• the fluid inlet extending along a first axis that is substantially perpendicular to the first fiber assembly, the fluid inlet having an inlet lumen and an internal curvilinear surface, the inlet lumen in fluid communication with the flow path;
• and
• the fluid outlet extending along a second axis that is substantially perpendicular to the first fiber assembly, the fluid outlet having an outlet lumen in fluid communication with the flow path;
• wherein the first axis extends through the potting material.