Ionization device
AssigneeKarsa Oy
InventorsJani Hakala, Jyri Mikkilä, Verner Hemmilä, Mikko Sipilä, Aleksei Shcherbinin, Hans-Jurg Jost
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Abstract
Disclosed are a multimethod ionization device (MID) to utilize at least chemical ionization and a system further utilizing such a device provided with a reaction chamber for ion formation of reagent species for adduct formation from at least one analyte to be characterized as based on mass to charge ratio for the analyte identification.
Claims20
A Dual MID-device (300A), wherein the Dual MID-device (300A) comprises at least two chambers (CH1), (CH2), a first chamber (CH1) and a second chamber (CH2), said chambers each being dedicated to a respective reagent species (R1), (R2), respectively, to have the sample (S) being exposed with, (101), as being divided by a divider (312b) into said chambers (CH1), (CH2), to a first sample part and a second sample part, each sample part with sample part specific sample analytes (R1), (R2) for getting mixed into chamber specific flows (301) in the chamber entry part of the port structure (312) with said reagents (R1), (R2), respectively, to expose each chamber specific sample-analyte reagent mixtures (S+R1), (S+R2) to ionization simultaneously, the reagent and sample analyte part together carrying the sample analyte and a reagent species to pass by the ionization source (302) that is arranged to ionize the sample analyte simultaneously together with the reagent species in each chamber (CH1), (CH2).
A MID-device (300B), wherein the MID-device (300B) comprises a plurality of rea gent flow introduction ports for each reagent (R1, R2), said introduction ports followed by an accelerator (403) provided with a ionization source (302) arranged to ionize each reagent species (R1), (R2) into ions (R1−), (R2−) to be accelerated by electro-magnetic fields (Ea), (Eb) before the reagent ion species (R1−), (R2−) entry to the reaction chamber (CH1), wherein the analytes in the sample introduction flow (301) to carry sample analytes to the reaction chamber (CH1) is/are arranged to mix with a at least one of the reagent ion species (R1−), (R2−), at the respective accelerator (403) outlet location to form adducts into the chamber volume (CH1), of the analyte species and the reagent ion species present in the chamber.
A MID-device (100), wherein the MID-device (100) comprises a port structure (312) further comprising at least one of the following ports:
- a reagent introduction port (104), sample introduction port (101, 101p), sheath flow introduction port (105), a flow laminarization assembly (FLA) arranged to be located at the sample entry part of the chamber (CH1) to make at least one of the sheath flow (105) and sample flow (101) laminar in the chamber (CH1), wherein the MID-device further comprises a ionization source (106) to ionize sample analytes and reagent species in the chamber part (102) of the chamber (CH1), wherein the sample flow channel (101) extending to the chamber (CH1) is arranged to guide the sample analytes in the core flow in the chamber (CH1) core part together with the reagent species, the core flow being surrounded by the sheath flow, the core flow carrying the sample analytes and a reagent species to pass by the ionization source (106) that is arranged to ionize the sample analyte molecules simultaneously together with the reagent species.
Dependencies are inferred from the claim text.