Left-right gene expression signature for triple negative breast cancer
AssigneeUniversity of South Carolina
InventorAnn F. Ramsdell
Life of this patent
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Abstract
Methods and materials are described for use in clinical and research applications directed to cancers. Products include binding arrays e.g., hybridization or other specific binding arrays such as genomic or proteomic microarrays. The binding arrays include binding agents developed based upon the recognition of heterogeneity between left-arising and right-arising breast cancer tumors. The arrays can include as binding agents materials that bind transcripts or proteins that are over-expressed in only one of or in both of left-arising or right-arising breast cancer tumors.
Claims7
A binding array comprising a plurality of binding agents adhered to a substrate, wherein the binding agents consist of polynucleotides that specifically hybridize to genes, or transcripts or cDNAs thereof, consisting of Abca4, Col6a2, Cspg4, Cthrc1, Dysf, Enho, Kcne3, Mmp9, Myh11, Nid2, Slc3a1, Stra6, Tmem47, and Usp13, and optionally include polynucleotides that specifically hybridize to genes, or transcripts or cDNA thereof, selected from the group consisting of:
- 2810454H06Rik, AA413626, Abcb4, Adam12, Adamts9, Akap12, Antxr1, Atp8b1, Bgn, Brinp3, C030037D09Rik, Ccdc80, Cdh2, Cdkn2b, Chsy3, Clca1, Cldn5, Clec11a, Clhc1, Cnih2, Col11a1, Col12a1, Col15a1, Col4a2, Col5a1, Col5a2, Col6a3, Col7a1, Cplx2, Crabp1, Creb311, Cttnbp2, Dmd, Egfl7, Ehd3, Emcn, Emx2, Epha3, Erg, Fam198b, Fam46b, Fhl1, Fjx1, Fmod, Gata6, Gcnt4, Gli2, Gm1141, Gpc4, Gpihbp1, Grem2, Gria3, Gucy1a2, Hey1, Heyl, Hmx2, Hoxb2, Hoxb7, Hoxb8, Hoxc8, Hs6st2, Htr1b, Htr2a, Igfbp3, Igfbp7, Itgb3, Jph2, Kcnb1, Kcnip4, Kcnmb1, Kcnq3, Kctd11, Khdrbs3, Klhl30, Krt42, Lama1, Lmo7, LOC100504703, Lpar4, Lrch2, Lrrc15, Lrrc55, Mcam, Mecom, Meox1, Mest, Mmp15, Mmrn1, Msx1, Mxra7, My19, Ncam1, Ndst3, Nexn, Nkd1, Nos3, Nrep, Oacyl, P4ha3, Palm2, Pcdh12, Pcdhga10, Pcsk9, Plet1os, Pnpla3, Ppbp, Prkd1, Prr9, Prss23, Ptprn, Rbp1, Rnf223, Ror2, Serp2, She, Slc12a3, Slc5a5, Slc8a3, Slit2, Snai2, Snhg18, Sobp, Sox17, Sparc, Srpx2, St8sia2, Syt5, Tacr1, Tagln, Tbx3, TIII, Tmem200a, Tmem204, Tmem252, Tnc, Tspan6, Ttc41, Unc5c, Wnt11, Glyctk, Sesn1, Gm4013, C1Gqa, Nr3c2, Cd200r4, Mag, Sc15a2, Lrfn1, Lefty1, Crym, Gm13710, Gpr82, Cc1l2, Aoah, Omp, Cd226, Epor, Rab39, Gzma, Sectm1a, Gm13154, Rnase6, and Cxc1l3.
Dependencies are inferred from the claim text.