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US 10,895,524 B2Granted
Biologic fluid sample analysis cartridge with non-reflective beads
AssigneeAbbott Point of Care Inc.
InventorsManav Mehta, Robert Holt
Life of this patent
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Abstract
A biological fluid sample analysis chamber and a method for analyzing a biological fluid sample is provided. The chamber includes a first chamber panel, a second chamber panel, and a plurality of beads disposed between the first chamber panel and the second chamber panel, which beads are configured to not reflect light incident to the beads in an amount that appreciably interferes with a photometric analysis of the biologic fluid.
Claims14
A method of analyzing a biological fluid sample, comprising:
- providing an analysis chamber defined by a first chamber panel having a first interior surface, and a second chamber panel having a second interior surface;
- disposing a biologic fluid sample in the analysis chamber, and quiescently holding the fluid sample in the analysis chamber, wherein the biologic fluid sample is mixed with at least one fluorescent dye configured to interact with the biologic fluid sample;
- disposing a plurality of beads, each bead having an exterior surface, between the interior surface of the first chamber panel and the interior surface of the second chamber panel, which beads are configured to not reflect light incident to the beads in an amount that appreciably interferes with a photometric analysis of the fluid sample, and wherein each of the beads is configured to inhibit the at least one fluorescent dye from attaching to the exterior surface of that bead;
- creating one or more images of the fluid sample using one or more wavelengths of light incident to the fluid sample, while the fluid sample is quiescently residing with the beads within the analysis chamber, and the beads are disposed within the chamber such that the exterior surface of each bead is in direct contact with the fluid sample during the creation of the images;
- and
- analyzing the quiescently residing fluid sample using at least a portion of the one or more images of the sample.
3 more elements
A method of analyzing a biological fluid sample, comprising:
- providing an analysis chamber defined by a transparent first chamber panel having a first interior surface, and a transparent second chamber panel having a second interior surface;
- disposing the biologic fluid sample in the analysis chamber, and quiescently holding the fluid sample in the analysis chamber;
- disposing a plurality of beads, each having an exterior surface, between the interior surface of the first chamber panel and the interior surface of the second chamber panel, which beads are configured to not reflect light incident to the beads in an amount that appreciably interferes with a photometric analysis of the fluid sample;
- creating one or more images of the fluid sample by transmitting light at one or more wavelengths of light through the fluid sample while the fluid sample is quiescently residing with the beads within the analysis chamber, and the beads are disposed within the chamber such that the exterior surface of each bead is in direct contact with the fluid sample during the creation of the images, wherein the one or more images are created using a captured portion of the light transmitted through the sample;
- and
- analyzing the quiescently residing fluid sample using at least a portion of the one or more images of the sample.
3 more elements
Dependencies are inferred from the claim text.