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US 10,894,839 B2Granted
Process for making Sugammadex
AssigneeSynthon BV
InventorArjanne Overeem
Life of this patent
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Abstract
The invention deals with a novel process for making the pharmaceutically useful product Sugammadex of formula (1)
Claims13
A process to synthesize Sugammadex comprising the steps of:
- a) substituting the primary hydroxyl groups of the γ-cyclodextrin by bromine to give the corresponding 6-per-deoxy-6-per-bromo-γ-cyclodextrin compound of formula (3),
- wherein X is Br;
- and
- b) reacting the compound of formula (3) with 3-mercaptopropionic acid in the presence of a sodium base and DMSO.
1 more element
Dependencies are inferred from the claim text.