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US 10,894,835 B2Granted
Antibodies to CD40 with enhanced agonist activity
AssigneeThe Rockefeller University
InventorsJeffrey V. Ravetch, Rony Dahan
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Abstract
Provided herein are agonistic antibodies, or antigen binding portions thereof, that bind to human CD40. Such antibodies optionally comprise Fc regions with enhanced specificity for FcγRIIb. The invention also provides methods of treatment of cancer or chronic infection by administering the antibodies of the invention to a subject in need thereof.
Claims10
An isolated antibody, or antigen binding portion thereof, that binds to human CD40 and comprises a heavy chain having the amino acid sequence of SEQ ID NO:
- 7 and a light chain having the amino acid sequence of SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.