Antibodies specifically binding PD-1, TIM-3 or PD-1 and TIM-3 and their uses
AssigneeJanssen Biotech, Inc.
InventorsRaluca Verona, Gordon Powers, Nina Chi Sabins, Nikki A DeAngelis, Sandra Santulli-Marotto, Karla R Wiehagen, Sheng-Jiun Wu, Catherine Ferrante, Enrique Zudaire Ubani
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Abstract
The present invention relates to antibodies specifically binding PD-1, TIM-3 or PD-1 and TIM-3, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.
Claims21
An isolated antagonistic antibody or an antigen-binding portion thereof specifically binding PD-1, comprising a heavy chain complementarity determining region (HCDR) 1 a HCDR2 and a HCDR3 of SEQ ID NOs:
- 10, 14 and 17, respectively, and a light chain complementarity determining region (LCDR)-1, a LCDR2 and a LCDR3 of SEQ ID NOs:
- 23, 26 and 32, respectively.
An isolated antagonistic antibody specifically binding PD-1 or an antigen-binding portion thereof, comprising
- a) the HCDR1, the HCDR2, the HCDR3, the LCDR1, the LCDR2 and the LCDR3 of SEQ ID NOs:
- 66, 67, 68, 69, 70 and 71, respectively;
- b) the VH of SEQ ID NO:
- 64 and the VL of SEQ ID NO:
- 65;
- and/or
- c) the HC of SEQ ID NO:
- 74 and the LC of SEQ ID NO:
- 75.
An isolated antagonistic antibody specifically binding PD-1 or an antigen-binding portion thereof, comprising a HCDR1, a HCDR2 and a HCDR3 of SEQ ID NOs:
- 11, 15 and 18, respectively and a LCDR1, a LCDR2 and a LCDR3 of SEQ ID NOs:
- 20, 30 and 32, respectively.
Dependencies are inferred from the claim text.