Antiretroviral drug targeting human endogenous retrovirus
AssigneeGeneuro SA
InventorsHerve Perron, Francois Curtin, Alois Lang, Raphael Faucard, Julie Medina, Alexandra Madeira, Nadege Gehin
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Abstract
The invention relates to an antibody, a fragment or a derivative thereof, for use as an antiretroviral drug targeting a virus belonging to human endogenous retroviruses type W (HERV-W), wherein said antibody, fragment or derivative thereof is directed against HERV-W Envelope protein (HERV-W Env). The invention also relates to a composition comprising said antibody and a retroviral reverse-transcriptase inhibitory drug, for use as an antiretroviral drug targeting a virus belonging to HERV-W.
Claims18
A method for inhibiting the expression and/or the replication of a virus belonging to a type W human endogenous retroviruses (HERV-W) in a patient, comprising administering to said patient a combined preparation comprising:
- an antibody or a fragment thereof, directed against HERV-W Envelope protein (HERV-W Env), wherein said antibody or fragment comprises each of the 6 CDRs as depicted in SEQ ID No:
- 1, SEQ ID No:
- 2, SEQ ID No:
- 3, SEQ ID No:
- 4, SEQ ID No:
- 5 and SEQ ID No:
- 6;
- and
- a retroviral reverse-transcriptase inhibitory drug.
A method for treating an HERV-W associated disease comprising administering to a patient in need thereof a combined preparation comprising:
- an antibody or a fragment thereof, directed against HERV-W Envelope protein (HERV-W Env), wherein said antibody or fragment comprises each of the 6 CDRs as depicted in SEQ ID No:
- 1, SEQ ID No:
- 2, SEQ ID No:
- 3, SEQ ID No:
- 4, SEQ ID No:
- 5 and SEQ ID No:
- 6;
- and
- a retroviral reverse-transcriptase inhibitory drug,
- said HERV-W associated disease being selected from the group consisting of multiple sclerosis (MS), schizophrenia (SZ), bipolar disorder (BP), unipolar or psychotic depression, clinically isolated syndrome (CIS, with neurological symptom), chronic inflammatory demyelinating polyneuropathy (CIDP), epilepsy, psoriasis, cancer, inflammatory pancreatitis and diabetes.
A method for inhibiting the expression and/or the replication of a virus belonging to a type W human endogenous retroviruses (HERV-W) in a patient, comprising administering to said patient a combined preparation consisting of:
- an antibody or a fragment thereof, directed against HERV-W Envelope protein (HERV-W Env), wherein said antibody or fragment comprises each of the 6 CDRs as depicted in SEQ ID No:
- 1, SEQ ID No:
- 2, SEQ ID No:
- 3, SEQ ID No:
- 4, SEQ ID No:
- 5 and SEQ ID No:
- 6;
- and
- a retroviral reverse-transcriptase inhibitory drug.
Dependencies are inferred from the claim text.