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AssigneeAmgen Inc.
InventorsYumei Xiong, Yi Zhang, Jackie Z. Sheng, Agnes Eva Hamburger, Murielle M. Veniant-Ellison, Grant Shimamoto, Xiaoshan Min, Zhulun Wang, Jie Tang, Gunasekaran Kannan, Marissa Mock, Kenneth William Walker
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Constructs comprising GDF15, and mutants thereof are provided. In various embodiments the constructs comprising GDF15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy.
A fusion protein comprising a GDF15 region and an Fc domain with an N297G mutation in its CH2 domain, wherein the Fc domain comprises the amino acid sequence of SEQ ID NO:
A dimer comprising (i) a first polypeptide chain comprising a GDF15 region and a first Fc domain with an N297G mutation in its CH2 domain, wherein the GDF15 region comprises an amino acid sequence that is at least 95 percent identical to SEQ ID NO:
The dimer of 11, wherein the polypeptide linker comprises the amino acid sequence of SEQ ID NO:
A tetramer comprising (i) a first dimer and (ii) a second dimer, wherein the first and second dimer independently comprise a dimer comprising (a) a first polypeptide chain comprising a GDF15 region and a first Fc domain with an N297G mutation in its CH2 domain, wherein the GDF15 region of the first polypeptide chain comprises an amino acid sequence that is at least 95 percent identical to SEQ ID NO:
Dependencies are inferred from the claim text.