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US 10,894,796 B2Granted
MK2 inhibitors, synthesis thereof, and intermediates thereto
AssigneeCelgene CAR LLC
InventorsGregg Brian Feigelson, Maryll E. Geherty, Richard Martin Heid, Jr., Mohit Kothare, Hon-Wah Man, Alexander L. Ruchelman, John F. Traverse, Kelvin Hin-Yeong Yong, Chengmin Zhang
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Abstract
The present invention provides methods of preparing a MK2 inhibitor, and intermediates related thereto.
Claims19
A method for preparing compound I:
- or a pharmaceutically acceptable salt thereof, comprising the steps of:
- reacting a compound of formula 1-11:
- or a salt thereof;
- with a compound of formula 1-12,
- wherein LG3 is a suitable leaving group;
- under suitable reaction conditions to provide compound I, or a pharmaceutically acceptable salt thereof;
- wherein the compound of formula 1-11 is prepared by a process comprising:
- reacting a compound of formula 1-10:
- or a salt thereof, wherein
- R′ is hydrogen or optionally substituted C1-6 aliphatic or aryl;
- under suitable reaction conditions to provide a compound of formula 1-11, or a salt thereof.
8 more elements
Dependencies are inferred from the claim text.