Phosphoinositide 3-kinase inhibitors with a zinc binding moiety

A compound represented by Formula (X) or Formula (XI),

• or a pharmaceutically acceptable salt thereof, wherein
• G1 is CR1, S, O, NR10 or NS(O)2R10;
• G2 is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or, substituted or unsubstituted heterocyclic;
• G4 is NR8, S or O;
• each R1 and R2 is independently selected from absent, hydrogen, hydroxy, amino, halogen, alkoxy, alkylamino, dialkylamino, CF3, CN, NO2, sulfonyl, acyl, aliphatic, substituted aliphatic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, and substituted heterocyclic;
• R10 is selected from hydrogen, hydroxy, amino, alkoxy, alkylamino, dialkylamino, sulfonyl, acyl, aliphatic, substituted aliphatic, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, and substituted heterocyclic;
• Ra and Rb, together with the nitrogen atom to which they are attached, form an optionally substituted heterocyclic group;
• R8 is hydrogen, acyl, aliphatic or substitute aliphatic;
• B is a direct bond or a linker;
• C is
• where R33 is hydrogen;
• n is 0, 1, 2, 3 or 4;
• o is 1, 2, 3, or 4;
• and
• p is 0 or 1.