Composition and method for treating metabolic disorders
AssigneeVeroScience LLC
InventorAnthony H. Cincotta
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AssigneeVeroScience LLC
InventorAnthony H. Cincotta
Estimating the term…
Bromocriptine citrate administered to a vertebrate, animal or human, can be used for any purpose including, e.g., the long-term modification and regulation of metabolic disorders, including prediabetes, obesity, insulin resistance, hyperinsulinemia, hyperglycemia and type 2 diabetes mellitus (T2DM) and/or, e.g., the treatment of other medical disorder(s) including immune or endocrine disorders or diseases. Bromocriptine citrate is administered over a limited or extended period at a time of day dependent on re-establishing the normal circadian rhythm of central dopaminergic activity of healthy members of a similar species and sex. Insulin resistance, hyperinsulinemia and hyperglycemia, T2DM, prediabetes, MS or all, can be controlled in humans on a long term basis by such treatment inasmuch as the daily administration of bromocriptine citrate resets neuronal activity timing in the neural centers of the brain to produce long term effects.
A method of treating non-alcoholic steatohepatitis (NASH) comprising parenterally administering to a patient suffering from NASH a pharmaceutical composition comprising between about 0.05 μg and 0.5 mg./kg of body weight per day of bromocriptine citrate administered to the patient between 0400 and 1200 hours of the day.
A method of treating non-alcoholic steatohepatitis (NASH) which comprises parenterally administering between about 0.05 μg and 0.5 mg./kg of body weight per day bromocriptine citrate at a time of day that will increase central dopaminergic activity of the patient at the time of day the circadian peak of central dopaminergic activity in a healthy individual of the same species and sex.
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