Method for the manufacturing of delmopinol
AssigneeLundbeck Pharmaceuticals Italy S.P.A.
InventorsCarla De Faveri, Mariano Stivanello
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Abstract
The present invention relates to a new process for producing 2-(3-(4-propylheptyl)morpholino)ethan-1-ol with the INN name Delmopinol. The invention also relates to three key intermediates 1-chloro-4-propylhept-3-ene, 1-iodo-4-propylhept-3-ene and 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol.
Claims20
A process for the manufacturing of delmopinol, or a pharmaceutically acceptable salt thereof, which process comprises the use of 1-halo-4-propylhept-3-ene.
A process for the manufacturing of delmopinol, or a pharmaceutically acceptable salt thereof, wherein a Grignard reagent prepared from 1-halo-4-propylhept-3-ene is reacted with oxazolidin[2,3-c]morpholine to provide 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol
- wherein said 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol is subsequently converted to delmopinol by catalytic hydrogenation
- optionally followed by reaction with an appropriate acid to achieve a pharmaceutically acceptable salt of delmopinol.
A process for manufacturing of delmopinol, which process comprises the use of 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol.
The compound 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.