TG2 inhibitor piperazine compounds and uses thereof

A compound of Formula I:

• or a pharmaceutically acceptable salt thereof,
• wherein:
• R1 is —C(O)—Ra;
• R2 is H or C1-6 alkyl, wherein C1-6 alkyl is optionally substituted with one or more substituents independently selected from the group consisting of C(O)NH2, C(O)OH, C(O)OC1-6 alkyl, NH2, NHC1-6 alkyl, N(C1-6 alkyl)2, OH, and OC(O)NH2;
• R3 is —C(O)—Re or —S(O)2—Rb;
• Ra is —CH2CH2-phenyl, —OCH2-phenyl, —OCH2-naphthalen-2-yl, —OCH2-pyridin-3-yl, —OCH2-quinolin-3-yl, phenyl, naphthalen-2-yl, or pyridin-3-yl;
• Rb is phenyl, naphthalen-1-yl, 5-(dimethylamino)naphthalen-1-yl, naphthalen-2-yl, 7-hydroxy-2H-chromen-2-on-3-yl, or 7-methoxy-2H-chromen-2-on-3-yl;
• and
• n is 1, 2, 3, or 4.