Drug delivery devices with drug-permeable component and methods
AssigneeTARIS Biomedical LLC
InventorHeejin Lee
Life of this patent
Estimating the term…
Abstract
Drug delivery devices having a drug-permeable component and methods of making and using the same are provided. Drug delivery devices include a housing having a first and second wall structures that are adjacent one another and together form a tube defining a drug reservoir lumen. The second wall structure, or both the first wall structure and the second wall structure, are permeable to water, and the first wall structure is impermeable to the drug while the second wall structure is permeable to the drug, such that the drug is releasable in vivo by diffusion through the second wall structure.
Claims20
A drug delivery device comprising:
- a housing comprising a first wall structure and a second wall structure that are integrally formed in a coextrusion process, and adjacent one another at two interface edges such that together the first and second wall structures form a tube defining a drug reservoir lumen;
- and
- a drug contained in the drug reservoir lumen,
- wherein:
- the second wall structure, or both the first wall structure and the second wall structure, are permeable to water,
- the first wall structure is impermeable to the drug and the second wall structure is permeable to the drug, such that the drug is releasable in vivo by diffusion through the second wall structure,
- the second wall structure comprises less than 90 percent of a cross sectional area of the tube, in a cross section normal to the longitudinal axis of the tube,
- the first wall structure comprises a first polyurethane composition, and
- the second wall structure is not bioerodible.
A drug delivery device comprising:
- a tubular housing having a closed drug reservoir lumen bounded by a wall structure comprising at least one thermoplastic material;
- and
- a drug contained in the drug reservoir lumen,
- wherein at least a portion of the wall structure is water permeable,
- wherein at least a portion of the wall structure is permeable to the drug such that the drug is releasable in vivo by diffusion through the drug permeable portion of the wall structure,
- wherein the wall structure comprises a first wall structure, which is impermeable to the drug, and a second wall structure that is not bioerodible, which is the drug permeable portion, and wherein the first and second wall structures are integrally formed in a coextrusion process, and adjacent one another such that together the first and second wall structures form the tubular housing,
- wherein the tubular housing is elastically deformable from a coiled retention shape suited to retain the device within the urinary bladder of a patient to an uncoiled shape suited for insertion of the device through the patient's urethra and into the bladder, and
- the tubular housing is thermally shape set to have the coiled retention shape.
Dependencies are inferred from the claim text.