Prosthetic implantable antibacterial surgical mesh

A method of making an implantable medical prosthetic mesh comprising nanofibers and a polymer mesh, said method comprising:

• mixing a first solution containing chitosan in an amount in the range of 0.5 wt. % to 5 wt. % with a second solution comprising an antibiotic in an amount in the range of 1.0 wt. % to 5.0 wt. % and a polymer blend in an amount in the range of 6 wt. % to 15 wt. %, and
• electrospinning the solution mixture to form the nanofibers, wherein the nanofibers comprise:
• the chitosan in an amount in the range of 8 wt. % to 35 wt. %, the chitosan having a degree of deacetylation in a range of 70% to 95%;
• the antibiotic in an amount in the range of 15 wt. % to 35 wt. %;
• and
• the polymer blend in an amount in the range of 45 wt. % to 70 wt. %, each weight percent relative to a total weight of the nanofibers,
• wherein the polymer blend comprises polyvinyl alcohol and polyvinylpyrrolidone;
• wherein an average diameter of the nanofibers is in a range of 50 nm to 300 nm;
• wherein the nanofibers have a bore size in a range of 300 nm to 900 nm, then
• depositing the nanofibers onto a mesh substrate to form the implantable medical prosthetic mesh having the nanofibers present on the surface of the mesh substrate;
• and
• wherein the antibiotic is released from the nanofibers steadily for at least 14 days, and wherein the implantable medical prosthetic mesh has an antibiotic release rate in a range of 0.01 μg/(cm2·min) to 10 μg/(cm2·min).