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US 10,894,097 B2Granted
HER2 binders
AssigneesGeneral Electric Company, Affibody AB
InventorsFaisal Ahmed Syud, Brian Duh-Lan Lee, Rong Zhang, Peter Brian Iveson, Paul Schaffer, Tove Simonsson, Elin Gunneriusson, Fredrik Frejd, Lars Abrahmsen, Joachim Feldwisch, Nina Herne, Christofer Lendel
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Abstract
Imaging agents comprising an isolated polypeptide conjugated with a radionuclide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
Claims10
A method of imaging at least a portion of a subject comprising:
- administering a composition to the subject, wherein the composition comprises an isolated polypeptide and an 18F coupled to the peptide through a bifunctional linker molecule, wherein the 18F is coupled to the bifunctional linker via an aminoxy group,
- wherein the isolated polypeptide comprises SEQ. ID No. 1 or SEQ. ID No. 2, and
- wherein the isolated polypeptide binds specifically to HER2;
- and
- imaging the subject with PET.
2 more elements
A method of imaging at least a portion of a subject comprising:
- administering a composition to the subject, wherein the composition comprises an isolated polypeptide comprising SEQ. ID No. 2 conjugated with a 18F via a tert-butyl 2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethylamino)-2-oxoethoxycarbamate linker, wherein the isolated polypeptide binds specifically to HER2;
- and
- imaging the subject with PET.
Dependencies are inferred from the claim text.