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US 10,894,094 B2Granted
Tetrapyrroles conjugates as MRI contrast agent
AssigneeNano4Imaging GmbH
InventorsFabian Kiessling, Paul Borm, Jozef Cremers, Nihan Güvener
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Abstract
The invention relates to the use of tetrapyrroles conjugated compounds as contrast agent in magnetic resonance imaging (MRI). In particular conjugates of natural hemin that can be embedded in gels and implants to image local delivery in MRI.
Claims5
Tetrapyrroles conjugated compounds according to formula (I)
- wherein,
- M consists of Fe, Ru, Os, Mn, Ni, Co
- Y consists F, Cl, Br, I, OH, pyridines, pyrazoles, imidazole, histidine, isothiocyanates, acetonitrile, methanol,
- wherein a linker with the formula (II)
- is located between the tetrapyrroles and at least one at least partly water-soluble compound R1 and R2,
- wherein R1, R2 consists of OH, SH, NH2, HisGLyOMe, polyurethanes, polyacrylates, polystyrenes, polyvinyllactams, PGLA, polyacrylic acid, PVP, hyaloronic acid, arginine, lysine, histidine, PEG, polyether amines, polylysine, polyarginine, polyhistidine and their salts, solvates and solvates of these salts.
3 more elements
Dependencies are inferred from the claim text.