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US 10,894,092 B2Granted
Nucleic acid products and methods of administration thereof
AssigneeFactor Bioscience Inc.
InventorsMatthew Angel, Christopher Rohde
Life of this patent
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Abstract
The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.
Claims11
A method for treating cancer comprising:
- contacting a tumor cell in a subject with a non-viral, cell-free composition comprising a synthetic messenger RNA (mRNA) encoding a gene-editing protein capable of creating a single-strand or double-strand break in an immune checkpoint molecule gene and
- causing a single-strand or double-strand break in the DNA of the tumor cell, the single-strand or double-strand break being localized to an immune checkpoint molecule gene in the tumor cell,
- resulting in the stimulation or enhancement of an immune response, thereby treating cancer in the subject.
Dependencies are inferred from the claim text.