Antibody drug conjugates (ADC) that bind to 191P4D12 proteins
AssigneesAgensys, Inc., Seagen Inc.
InventorsDaulet Satpayev, Robert Kendall Morrison, Karen Jane Meyrick Morrison, Jean Gudas, Aya Jakobovits, Michael Torgov, Zili An
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Abstract
Antibody drug conjugates (ADC's) that bind to 191P4D12 protein and variants thereof are described herein. 191P4D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention provide a therapeutic composition for the treatment of cancer.
Claims38
An antibody drug conjugate comprising an anti-191P4D12 antibody or antigen binding fragment thereof, wherein the antibody or antigen binding fragment thereof comprises a heavy chain variable region comprising complementarity determining regions (CDRs) comprising the amino acid sequences of the CDRs in the heavy chain variable region sequence set forth in SEQ ID NO:
- 7 and a light chain variable region comprising CDRs comprising the amino acid sequences of the CDRs in the light chain variable region sequence set forth in SEQ ID NO:
- 8, and wherein the antibody or antigen binding fragment thereof is conjugated to 2 to 8 units of a cytotoxic or cytostatic agent, each unit being conjugated via a linker to the antibody or antigen binding fragment thereof.
Dependencies are inferred from the claim text.