US 10,894,088 B2Granted

BSH complex for boron neutron capture therapy

AssigneeNational University Corporation Okayama University

InventorsHideki Matsui, Shuichi Furuya, Hiroyuki Michiue, Hiroki Kakuta, Yasuaki Takeuchi

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Abstract

The present invention provides: a complex of a mercaptoundecahydrodecaborate (BSH) and a peptide, the complex for boron neutron capture therapy (BNCT); a method for producing the complex; and a cancer therapy using the complex.

Claims10

Dependent claims

A complex, comprising a peptide comprising a repeating hydrophobic amino acid residue and a basic amino acid residue and BSH, wherein the complex is in a spherical shape having a diameter of about 20 nm to about 200 nm.

Dependencies are inferred from the claim text.

Facts

Application: 16/463,747Filed 24 Nov 2017
Priority: JP 2016-22930225 Nov 2016
Published: US 2020/0121800 A123 Apr 2020
Granted: 19 Jan 2021
Term ends: Not estimatedThe source records don’t support an estimate.

Classification13 codes

A61K 47/64
The modifying agent being a protein, peptide or polyamino acid: drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying…
A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61K 31/095
Medicinal preparations containing organic active ingredients: sulfur, selenium, or tellurium compounds, e.g. thiols
A61K 31/19
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids: carboxylic acids, e.g. valproic acid

Family

US 2020/0121800 A1Pre-grant publication · published 23 Apr 2020
US 10,894,088 B2This patent

From the US filing history. Foreign family members aren’t listed.

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