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US 10,894,087 B2Granted
Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
AssigneeNektar Therapeutics
InventorAntoni Kozlowski
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Abstract
Among other aspects, provided herein are multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds. Methods of preparing such conjugates as well as methods of administering the conjugates are also provided. Upon administration to a patient, release of the cabazitaxel-based compound is achieved.
Claims8
A conjugate of formula:
- wherein:
- each R1 is methyl;
- each R2 is methyl;
- each X is —(CH2)m— or —CH2C(O)NHCH(R3)—;
- each m is a positive integer from 1 to about 12;
- R3 is —H;
- and
- each n is a positive integer from 10 to about 400;
- or pharmaceutically acceptable salts and solvates thereof;
- wherein the conjugate has an increased tumor growth delay compared to cabazitaxel.
7 more elements
Dependencies are inferred from the claim text.