System for thermotherapy treatment or prevention of antimicrobial resistant or biofilm infections

A method of thermotherapy treatment of antimicrobial resistant or biofilm infections in a patient infected, the method comprising:

• conveying to a localized area of an organism infected by microorganisms a support configured to be conveyed towards the localized area, the support configured to receive a nanoparticle assembly (NPA) and the support comprising the NPA comprising a plurality of nanoparticles each one having a silver core and a surface surrounding the silver core, wherein the silver core is reactable to thermal energy;
• and wherein the nanoparticles have attached on the surface at least the antimicrobial agent amikacin and wherein the surface of each nanoparticle comprises a mPEG covering;
• and
• applying, by an energy unit, at least one thermal shot to the localized area, increasing the temperature of said localized area to a given value via the NPA, so enabling a nanotheranostic multimodal antimicrobial therapy.