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US 10,894,083 B2Granted
Stable aqueous anti-vascular endothelial growth factor (VEGF) antibody formulation
AssigneePfizer Inc.
InventorsRebecca Lee Ingram, Sarah Elizabeth Weiser
Life of this patent
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Abstract
The present invention relates to the field of pharmaceutical formulations of antibodies. Specifically, the present invention relates to a stable liquid antibody formulation and its pharmaceutical preparation and use. This invention is exemplified by an aqueous formulation of an anti-vascular endothelial growth factor (VEGF) antibody.
Claims5
An aqueous formulation comprising:
- about 25 mg/ml of an anti-vascular endothelial growth factor (VEGF) antibody;
- about 20 mM histidine or succinate buffer;
- about 85 mg/mL sucrose;
- about 0.2 mg/ml polysorbate 80;
- about 0.05 mg/ml EDTA;
- wherein the antibody comprises a heavy chain variable region comprising the amino acid sequence of SEQ ID NO:
- 7, and a light chain variable region comprising the amino acid sequence of SEQ ID NO:
- 8;
- and
- wherein the formulation has pH at about 5.5 or 5.8.
7 more elements
Dependencies are inferred from the claim text.