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AssigneeLanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences
InventorsHaixue Zheng, Fan Yang, Zixiang Zhu, Weijun Cao, Hong Tian, Keshan Zhang, Dan Li, Ye Jin, Jianhong Guo, Jijun He, Xuepeng Cai, Xiangtao Liu
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The present disclosure relates to a foot-and-mouth disease virus vaccine composition, especially a recombinant bivalent vaccine composition against type O and type A foot-and-mouth disease viruses. The present disclosure further relates to a method for preparing the foot-and-mouth disease virus vaccine composition, and a use of the foot-and-mouth disease virus vaccine composition in preparing medicines for preventing and/or controlling foot-and-mouth disease in animals.
A bivalent foot-and-mouth disease virus (FMDV) vaccine composition comprising a first FMDV vaccine and a second FMDV vaccine, the first FMDV vaccine comprising a first FMDV which contains or is encoded by first recombinant FMDV nucleic acids, the sequence of the first recombinant FMDV nucleic acids comprises a nucleic acid sequence of a FMDV O/CHA/99 strain, but in the nucleic acid sequence of the FMDV O/CHA/99 strain, 177 consecutive nucleotides in the L gene connected with P1 gene, all of the P1 gene, and 1206 consecutive nucleotides in the P2 gene connected with the P1 gene are replaced as a whole by a sequence shown in SEQ ID NO:
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