Composition comprising GLP-1 receptor agonist and glucagon receptor agonist and application thereof

A pharmaceutical composition comprising:

• a pharmaceutically effective amount of a glucagon-like peptide-1 (GLP-1) receptor agonist and a glucagon receptor agonist,
• wherein the GLP-1 receptor agonist and the glucagon receptor agonist each independently form a conjugate with a hydrophilic polymer, wherein:
• the GLP-1 receptor agonist is selected from the group consisting of Exendin-4, Exendin-3, GLP-1 and PB-105, and the glucagon receptor agonist is selected from the group consisting of PB-702, PB-703, PB-740 and PB-741, wherein
• PB-105 has the amino acid sequence set forth in SEQ ID NO:
• 1;
• PB-702 has the amino acid sequence set forth in SEQ ID NO:
• 3;
• PB-703 has the amino acid sequence set forth in SEQ ID NO:
• 4;
• PB-740 has the amino acid sequence set forth in SEQ ID NO:
• 5;
• and
• PB-741 has the amino acid sequence set forth in SEQ ID NO:
• 6;
• the hydrophilic polymer is a polyethylene glycol (PEG);
• and
• the molar ratio of the GLP-1 receptor agonist to the glucagon receptor agonist is 1:3 to 1:10.