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US 10,894,057 B2Granted
Glycan therapeutic compositions and related methods thereof
AssigneeKaleido Biosciences, Inc.
InventorsGeoffrey A. von Maltzahn, Yvonne J. Yamanaka, Jared Silverman, John Miles Milwid, Jacob Rosenblum Rubens, John M. Geremia
Life of this patent
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Abstract
Preparations of glycan therapeutics, pharmaceutical compositions, dietary supplements and medical foods thereof are provided, and methods of using said gycan therapeutics, e.g. in cancer therapy.
Claims23
A method of treating cancer in a subject, comprising administering to the subject an effective amount of a composition comprising a glycan therapeutic preparation, wherein
- i) the glycan therapeutic preparation comprises branched glycans comprising glucose, galactose, arabinose, mannose, fructose, xylose, fucose, or rhamnose glycan units;
- ii) the average degree of branching (DB) of the branched glycans in the glycan therapeutic preparation is at least 0.01;
- iii) at least 50% of the glycans in the glycan therapeutic preparation have a degree of polymerization (DP) of at least 3 and less than 30 glycan units;
- and
- iv) the ratio of alpha- to beta-glycosidic bonds present in the glycans of the glycan therapeutic preparation is between about 1:1 to about 5:1;
- and
- wherein the composition is administered in combination with an anti-cancer drug or anti-cancer therapy.
4 more elements
Dependencies are inferred from the claim text.