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US 10,894,049 B2Granted
Pharmaceutical formulation of palbociclib and a preparation method thereof
AssigneeShenzhen Pharmacin Co., Ltd.
InventorsZeren Wang, Jun Xu, Long Qu
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Abstract
The present invention belongs to the pharmaceutical field, and in particular, it relates to a pharmaceutical formulation of palbociclib and a preparation method thereof. The pharmaceutical formulation comprises palbociclib, an acidic auxiliary material, and optionally a hydrophilic high-molecular material, which has better solubility and in vitro dissolution property as compared with the conventional formulation and can be used for enhancing in vivo absorption and bioavailability of palbociclib.
Claims13
A method for treating breast cancer, comprising:
- administering to a subject having breast cancer a pharmaceutical composition, wherein the pharmaceutical composition comprises an amorphous solid dispersion, wherein the amorphous solid dispersion comprises the following in an amorphous state:
- palbociclib or a pharmaceutically acceptable salt thereof;
- tartaric acid;
- and
- a hydrophilic high-molecular weight material.
2 more elements
Dependencies are inferred from the claim text.