Inhibitors of bacterial two component signal transduction system and uses thereof
AssigneeAcademia Sinica
InventorsChinpan Chen, Tien-Sheng Tseng, Keng-Chang Tsai
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Abstract
Disclosed herein are novel uses of a compound of formula (I) as an inhibitor of bacterial two component signal transduction system (TCS), A-L-B-L-A (I) wherein, A is a moiety having a negative charge; L is —(C2H5—O)n—CH2— or a moiety consists of a carbocyclyl and a heterocyclyl respectively having 5 to 10 ring atoms and coupling together, in which n is 0 or 1; and B is a 5 to 10-membered carbocyclyl or heterocyclyl. The compound of formula (I) may suppress or inhibit the growth of bacteria, including the notorious multi-drug resistant bacteria.
Claims5
A method of inhibiting bacterial growth in a subject, comprising administering to the subject, an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt, hydrate or solvate thereof,
- A-L-B-L-A (I)
- wherein,
- A is a moiety having a negative charge, which is selected from the group consisting of PO4−, PO32−, and SO3−;
- L is
- and
- B is —C6H4—;
- an antibiotic selected from the group consisting of colistin, polymyxins, rapamycins, and a combination thereof, and
- the bacteria is any of Escherichia Coli, Klebsiella pneumoniae, or Staphylococcus aureus.
Dependencies are inferred from the claim text.