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US 10,894,033 B2Granted
Multicyclic compounds and methods of use thereof
AssigneesSunovion Pharmaceuticals Inc., PGI Drug Discovery LLC
InventorsLiming Shao, John Emmerson Campbell, Michael Charles Hewitt, Una Campbell, Taleen G. Hanania
Life of this patent
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Abstract
Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.
Claims21
A compound of formula:
- or a pharmaceutically acceptable salt or stereoisomer thereof.
A compound of formula:
- or a pharmaceutically acceptable salt or stereoisomer thereof.
A method of producing N-methyl-1-(5,6-dihydro-4H-cyclopenta[b]thiophen-4-yl)methanamine:
- or a pharmaceutically acceptable salt or stereoisomer thereof, by treating (5,6-dihydro-4H-cyclopenta[b]thiophen-4-yl)methanamine with ethyl chloroformate to produce ethyl ((5,6-dihydro-4H-cyclopenta[b]thiophen-4-yl)methyl)carbamate, and reducing said ethyl ((5,6-dihydro-4H-cyclopenta[b]thiophen-4-yl)methyl)carbamate to form N-methyl-1-(5,6-dihydro-4H-cyclopenta[b]thiophen-4-yl)methanamine.
A compound:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.