Neuroprotective compositions and their use
AssigneeSami Labs Limited
InventorsMuhammed Majeed, Kalyanam Nagabhushanam
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Abstract
Disclosed are compositions containing not less than 10% w/w of oroxylin A, not less than 10% w/w of baicalein and not less than 2% w/w of chrysin for use in the therapeutic management of memory impairment and cognitive dysfunction. More specifically, the invention discloses the use of abovementioned compositions for the management of cognitive impairment induced by chemotherapy and hyperglycemia.
Claims12
A method of therapeutic management of neurotoxicity in mammals, said method comprising steps of administering effective concentration of a composition consisting essentially of 10%-15% w/w of oroxylin A, 10%-25% w/w of baicalein and 2%-10% w/w of chrysin, to mammals in need of such therapeutic management, wherein neurotoxicity is induced by chemotherapeutics;
- wherein the composition confers neuroprotection by improving cognition, decreasing oxidative stress, and enhancing mitochondrial function in the brain of mammals.
A method of therapeutic management of hyperglycemia induced neurotoxicity in mammals, said method comprising steps of administering effective concentration of a composition consisting essentially of 10%-15% w/w of oroxylin A, 10%-25% w/w of baicalein and 2%-10% w/w of chrysin, to mammals in need of such therapeutic management, wherein the composition confers neuroprotection by decreasing oxidative stress and enhancing mitochondrial function in the brain of mammals, thereby improving cognition.
Dependencies are inferred from the claim text.