Methods of modifying the porous surface of implants
AssigneeBiomet Manufacturing, LLC
InventorsDevendra Gorhe, Donald L. Yakimicki, Philip McBride
Life of this patent
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Abstract
Methods are provided for modifying a porous surface of an implantable medical device by subjecting the porous surface to a modified micro-arc oxidation process to improve the ability of the medical device to resist microbial growth, to improve the ability of the medical device to adsorb a bioactive agent or a therapeutic agent, and to improve tissue in-growth and tissue on-growth of the implantable medical device.
Claims10
A method of modifying a surface of an orthopedic implant, comprising:
- providing an orthopedic implant comprising a non-porous surface and a porous oxide layer;
- forming an electrolytic cell including an anode comprising the porous oxide layer;
- causing micro-arc oxidation in the electrolytic cell to form a plurality of micro-pores in the porous oxide layer;
- and
- after forming the plurality of micro-pores, depositing a therapeutic agent on the medical device including performing a first deposition process to deposit the therapeutic agent on the non-porous surface of the implant and performing a second deposition process to deposit the therapeutic agent on the micro-porous oxide layer the second deposition process different from the first deposition process.
A method of modifying a surface of an orthopedic implant having a non-porous surface and a porous surface;
- the method comprising:
- providing an electrolytic cell comprising a cathode, a first electrolyte solution including a glycol, a dispersant, or a surfactant wherein the orthopedic implant is an anode of the electrolytic cell;
- maintaining the electrolyte solution at a temperature of about 10° C. or less;
- causing micro-arc oxidation at the porous surface of the orthopedic implant to form a plurality of micro-pores in the porous surface, including applying a rectified sine waveform that is pulsed at a frequency between 10 Hz and 150 Hz and has a peak voltage between 100 volts and 1000 volts;
- after forming the plurality of micro-pores, using the orthopedic implant as an anode of a second electrolytic cell comprising a second electrolyte solution and a therapeutic agent;
- and
- causing anodic deposition of the therapeutic agent on the non-porous surface of the orthopedic implant before causing anodic deposition of the therapeutic agent on the micro-porous surface of the orthopedic implant.
Dependencies are inferred from the claim text.