Methods and devices to detect the presence of a condition associated with ATP depletion in a subject
AssigneeSarissa Biomedical Limited
InventorsNicholas Dale, Chris Imray, Bruno Frenguelli
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Abstract
The invention provides a method of determining a predisposition to a condition associated with ATP depletion, such as an ischaemic event, in a subject comprising: a. measuring the concentration of one or more purines in a body fluid of the subject, the purines being selected from adenosine, inosine, hypoxanthine, xanthine and ATP, and b. comparing the measured concentration with a threshold concentration of the one or more purines, wherein the threshold concentration is preferably in the range 2 [micro]M to 8 [micro]M and wherein a measured concentration higher than the threshold concentration indicates the presence of ischaemia.
Claims22
A method of determining a predisposition to a chronic ischaemic condition or an acute ischaemic condition associated with ATP depletion in a subject, the method comprising:
- a. measuring the concentration of one or more purines in a body fluid of the subject using a biosensor comprising an electrochemical cell, where the purines are selected from the group consisting of adenosine, inosine, hypoxanthine, xanthine, and ATP, and
- b. comparing the measured concentration with a threshold concentration of the one or more purines, wherein the threshold concentration is in the range from about 2 μM to about 8 μM, and wherein a measured concentration higher than the threshold concentration indicates the presence of the condition.
A method of determining a predisposition to a condition associated with ATP depletion in a subject, the method comprising:
- a. measuring an equivalent total purine concentration measured by a measurement device responsive to two or more of said purines, where the purines are selected from the group consisting of adenosine, inosine, hypoxanthine, xanthine, and ATP;
- and where the total purine measurement is calibrated relative to the response of the measurement to a single calibration purine;
- and
- b. comparing the measured concentration with a threshold concentration, wherein the threshold concentration is in the range from about 2 μM to about 8 μM, and wherein a measured concentration higher than the threshold concentration indicates the presence of the condition.
A method of determining a predisposition to a chronic ischaemic condition or an acute ischaemic condition associated with ATP depletion in a subject, the method comprising:
- measuring the concentration of one or more purines in a body fluid of a subject at two or more time points using a biosensor comprising an electrochemical cell, where the purines are selected from the group consisting of adenosine, inosine, hypoxanthine, xanthine, and ATP, and deriving the rate of change of the measured concentration, and
- comparing the rate of change with a threshold value for the rate of change, where a rate of change above the threshold rate of change indicates that the condition is present.
Dependencies are inferred from the claim text.