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US 10,884,001 B2Granted
Diagnosis of chronic liver diseases
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorsDetlef Schuppan, Towia Libermann, Simon T. Dillon, Yury Papou
Life of this patent
Estimating the term…
Abstract
Featured are methods of diagnosing and treating liver disease.
Claims9
A method comprising the steps of:
- a) measuring in a biological sample from a human or animal subject suspected of having a liver disease a level of two or more protein biomarkers selected from the group consisting of:
- Transmembrane protein 206, Kininogen-1, ubiquitin protein ligase E3 component N-recognin 3 (UBR3), Mucin-6, Nesprin-1, Protein Family with Sequence Similarity 71 Member B (FAM71B), and peptide fragments thereof, and
- b) administering a treatment for said liver disease to said subject having an increased level of at least two of said biomarkers, as compared to a control.
A method of measuring a level of two or more protein biomarkers, said method comprising:
- a) contacting a biological sample from a subject suspected of having a liver disease with detecting agents that bind two or more protein biomarkers selected from the group consisting of:
- Transmembrane protein 206, Kininogen-1, UBR3, Mucin-6, Nesprin-1, Protein FAM71B, and peptide fragments thereof, and
- b) measuring the level of said biomarkers in the sample that are bound by the detecting agents.
Dependencies are inferred from the claim text.