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US 10,883,997 B2Granted
Polyspecificity reagents, methods for their preparation and use
AssigneeAdimab, LLC
InventorsPiotr Bobrowicz, Amber D. Hanna, Jerry M. Thomas
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Abstract
The present invention relates, inter alia, to polyspecificity reagents, methods of making the same, and methods of using the same in, inter alia, the selection, screening, enrichment, and identification of non-polyspecific, and thus developable, polypeptides.
Claims13
A method of counter-selecting against at least one polyspecific polypeptide from a plurality of polypeptides, the method comprising:
- (a) providing the plurality of polypeptides;
- (b) contacting the plurality of step (a) with a polyspecificity reagent, wherein the polyspecificity reagent comprises a soluble cellular fraction, thereby producing a reagent-plurality mixture;
- (c) detecting from the reagent-plurality mixture of step (b) at least one polyspecific polypeptide that interacts with the polyspecificity reagent, thereby detecting at least one polyspecific polypeptide;
- and
- (d) selecting at least one polypeptide from the plurality that is not detected in step (c), thereby counter-selecting against the at least one polyspecific polypeptide from the plurality of polypeptides.
2 more elements
Dependencies are inferred from the claim text.