P53 biomarkers

A method of treating a human subject using p53 gene therapy comprising identifying a human subject having a tumor, wherein cells of the tumor:

• i) comprise two wild type p53 alleles;
• ii) express a level of mutant p53 protein that forms inactivating tetramers that is not higher than that expressed in normal p53-expressing non-tumor cells, or
• iii) express a mutant p53 protein that does not form inactivating tetramers;
• wherein if cells of the subject's tumor exhibits at least one of i), ii) or iii), then treating the subject with the p53 gene therapy.