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US 10,883,937 B2Granted
Detector with reduced fluorescence range noise
AssigneeIllumina, Inc.
InventorsTracy H. Fung, Poorya Sabounchi, Bernard Hirschbein, Joseph Pinto, Tarun Khurana, Randall Smith, Wenyi Feng
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Abstract
There is set forth herein a device comprising structure defining a detector surface configured for supporting biological or chemical substances, and a sensor array comprising light sensors and circuitry to transmit data signals using photons detected by the light sensors. The device can include one or more features for reducing fluorescence range noise in a detection band of the sensor array.
Claims20
A device comprising:
- a detector surface configured for supporting biological or chemical samples;
- a sensor array comprising light sensors and light guides;
- wherein the light guides receive excitation light and emissions signal light from the detector surface, wherein the light guides extend toward respective light sensors of the sensor array and comprise filter material, and wherein the filter material comprises a metal complex dye.
A method comprising:
- depositing filter material within guide cavities of a guide cavity array that are aligned with and disposed above respective light sensors of a light sensor array, wherein the filter material comprises dye having a photon emission quencher;
- and
- fabricating a structure defining a detector surface for supporting biological or chemical samples above cavities of the guide cavity array and light sensors of the light sensor array.
A device comprising:
- a detector surface for supporting biological or chemical samples;
- a sensor array comprising light sensors;
- and
- light guides;
- wherein light guides receive excitation light and emissions signal light from the detector surface, wherein the light guides extend toward respective light sensors of the sensor array, wherein the detector surface includes a reaction recess, the reaction recess comprising an index of refraction and a dimension sufficient to cancel background light energy incident on the detector surface in a detection band of the sensor array.
2 more elements
Dependencies are inferred from the claim text.