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US 10,883,118 B2Granted
Agents for improved delivery of nucleic acids to eukaryotic cells
AssigneeMolecular Transfer, Inc.
InventorsJoel Jessee, Gulilat Gebeyehu
Life of this patent
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Abstract
New cationic lipids are provided that are useful for delivering macromolecules, such as nucleic acids, into eukaryotic cells. The lipids can be used alone, in combination with other lipids and/or in combination with other transfection enhancing reagents to prepare transfection complexes.
Claims18
A composition comprising a compound having the structure
- wherein each R1 independently is C1-C23 alkyl, C1-C23 alkenyl, (CO)C1-C23 alkyl, or (CO)C1-C23 alkenyl;
- and
- each R2 independently is —CH2—(CHR3)1-6—CH2—NHR4 or —CH2—(CHR3)0-6—CH2—OH, wherein each R3 independently is H, OH, or NH2,
- R4 is H or CH3;
- and
- R10 is H or C1-C8 alkyl;
- and an amphipathic peptide.
4 more elements
Dependencies are inferred from the claim text.