Polynucleotide agents targeting factor XII (hageman factor) (F12) and methods of use thereof
AssigneeAlnylam Pharmaceuticals, Inc.
InventorGregory Hinkle
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Abstract
The invention relates to polynucleotide agents targeting Factor XII (F12) gene, and methods of using such polynucleotide agents to inhibit expression of Factor XII and to treat subjects having a Factor XII-associated disease, e.g., heredity angioedema (HAE), prekallikrein deficiency, malignant essential hypertension, hypertension, end stage renal disease, or Fletcher Factor Deficiency.
Claims18
A single stranded antisense polynucleotide agent for inhibiting expression of a Factor XII (F12) gene, wherein the agent comprises 14 to 20 contiguous nucleotides, wherein at least one of the contiguous nucleotides is a modified nucleotide, and wherein the nucleotide sequence of the agent is fully complementary over its entire length to nucleotides 287-306 of SEQ ID NO:1.
Dependencies are inferred from the claim text.