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US 10,883,095 B1Granted
Mad nucleases
AssigneeInscripta, Inc.
InventorsBenjamin Mijts, Juhan Kim, Aamir Mir, Andrew Garst, Kyle Seamon
Life of this patent
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Abstract
The present disclosure provides new RNA-guided nucleases for making rational, direct edits to nucleic acids in live cells.
Claims6
A nuclease system for performing nucleic acid-guided nuclease editing, wherein the nuclease system is selected from a nuclease system comprising SEQ ID NO:
- 7, SEQ ID NO:
- 26 and SEQ ID NO:
- 27;
- a nuclease system comprising SEQ ID NO:
- 7, SEQ ID NO:
- 28 and SEQ ID NO:
- 29;
- and a nuclease system comprising SEQ ID NO:
- 7, SEQ ID NO:
- 30 and SEQ ID NO:
- 31.
8 more elements
A nickase having an amino acid sequence selected from SEQ ID NOs:
- 17 and 18.
A dead nuclease having an amino add sequence of SEQ ID NO:
- 19.
Dependencies are inferred from the claim text.