Antibodies against HPA-1a
AssigneeRallybio IPA, LLC
InventorsTerje Michaelsen, Oistein Ihle, Tor Brynjar Stuge, Anne Husebekk, Heidi Tiller, Mariana Eksteen, Bjorn Ragnar Skogen
Life of this patent
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Abstract
The present invention provides an isolated antibody that specifically binds to HPA-1a. Also provided is a nucleic acid molecule that encodes the antibody, and compositions comprising the antibody. Also provided is a method of producing the antibody and methods and uses which employ the antibody. Also provided are therapeutic uses of the antibody, for example in the treatment or prophylaxis of fetal and neonatal alloimmune thrombocytopenia (FNAIT).
Claims17
An isolated antibody that specifically binds to HPA-1a and that comprises at least one heavy chain variable region that comprises three CDRs and at least one light chain variable region that comprises three CDRs, wherein said light chain variable region comprises:
- (a) a variable light (VL) CDR1 that has the amino acid sequence of SEQ ID NO:8;
- (b) a VL CDR2 that has the amino acid sequence of SEQ ID NO:9;
- and
- (c) a VL CDR3 that has the amino acid sequence of SEQ ID NO:
- 10;
- and wherein said heavy chain variable region comprises:
- (d) a variable heavy (VH) CDR1 that has the amino acid sequence of SEQ ID NO:5;
- (e) a VH CDR2 that has the amino acid sequence of SEQ ID NO:6;
- and
- (f) a VH CDR3 that has the amino acid sequence of SEQ ID NO:7.
Dependencies are inferred from the claim text.