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US 10,882,917 B2Granted
Anti-tumor agents and methods of use
AssigneeThe Rockefeller University
InventorsMikael Karlsson, Jeffrey V. Ravetch
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Abstract
The present invention relates to anti-tumor agents that target certain tumor-associated macrophages. Also disclosed are methods of using such agents in treatment of cancer.
Claims8
An isolated antibody or an antigen-binding fragment thereof that specifically interacts and shows a measurable affinity to a macrophage receptor with collagenous structure (MARCO) epitope, comprising
- (i) a heavy chain comprising heavy chain CDRs 1-3 of SEQ ID NO:
- 3 and
- (ii) a light chain comprising light chain CDRs 1-3 of SEQ ID NO:
- 5,
- wherein the light chain differs from SEQ ID NO:
- 5 or the heavy chain differs from SEQ ID NO:
- 3.
4 more elements
Dependencies are inferred from the claim text.