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US 10,882,916 B2Granted
Anti-C5a receptor antibodies
AssigneeNovo Nordisk A/S
InventorsKristian Kjaergaard, Soeren Lund, Stefan Zahn, Louise H. Zeuthen, Anker J. Hansen
Life of this patent
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Abstract
The present invention concerns human antibodies recognising the human C5a receptor. By binding to C5aR the antibodies inhibit C5a signalling, whereby the pro-inflammatory signal is inhibited. Based on the role of C5a and its receptor in stimulation of inflammation the invention further relates to therapeutic use of said human anti-C5aR antibodies and in particular in relation to treatment of immunological disorders.
Claims14
An antibody that specifically binds C5aR, wherein the antibody comprises a light chain variable region comprising:
- a CDR1 sequence comprising SEQ ID 5, 13, 21 or 29;
- a CDR2 sequence comprising SEQ ID 6, 14, 22 or 30;
- and a CDR3 sequence comprising SEQ ID 7, 15, 23 or 31.
Dependencies are inferred from the claim text.