Anti-DR5 antibodies and methods of use thereof

A composition comprising:

• (a) a first antibody that binds to human DR5 and comprises a heavy chain variable (VH) region and a light chain variable (VL) region, wherein the VH region comprises VHCDR1, VHCDR2, and VHCDR3 domains comprising the amino acid sequences set forth in SEQ ID NOs:
• 1, 8, and 3, respectively, and the VL region comprises VLCDR1, VLCDR2, and VLCDR3 domains comprising the amino acid sequences set forth in SEQ ID NO:
• 5, the sequence FAS, and SEQ ID NO:
• 6, respectively, and
• (b) a second antibody that binds to human DR5 and comprises VH and VL regions, wherein the VH region comprises VHCDR1, VHCDR2, and VHCDR3 domains comprising the amino acid sequences set forth in SEQ ID NOs:
• 10, 2, and 11, respectively, and the VL region comprises VLCDR1, VLCDR2, and VLCDR3 domains comprising the amino acid sequences set forth in SEQ ID NO:
• 13, the sequence RTS, and SEQ ID NO:
• 14, respectively,
• wherein both the first antibody and second antibody comprise a Fc region of a human immunoglobulin IgG, and wherein in the Fc region of both the first antibody and second antibody, the amino acid at the position corresponding to E430 in human IgG1 is mutated to G.

A composition comprising:

• (a) a first antibody that binds to human DR5 and comprises a heavy chain variable (VH) region and a light chain variable (VL) region comprising the amino acid sequences set forth in SEQ ID NOs:
• 9 and 7, respectively, and
• (b) a second antibody that binds to human DR5 and comprises a VH region and a VL region comprising the amino acid sequences set forth in SEQ ID NOs:
• 12 and 15, respectively,
• wherein both the first antibody and second antibody comprise a Fc region of a human immunoglobulin IgG, and wherein in the Fc region of both the first antibody and second antibody, the amino acid at the position corresponding to E430 in human IgG1 is mutated to G.

A composition comprising:

• (a) a first antibody that binds to human DR5 and comprises a heavy chain and a light chain comprising the amino acid sequences set forth in SEQ ID NOs:
• 38 and 39, respectively, and
• (b) a second antibody that binds to human DR5 and comprises a heavy chain and a light chain comprising the amino acid sequences set forth in SEQ ID NOs:
• 42 and 43, respectively.