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US 10,882,911 B2Granted
CD40L binding polypeptide
AssigneeSeoul National University R&Db Foundation
InventorsSeongHoe Park, Kyeong Cheon Jung
Life of this patent
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Abstract
Disclosed is a CD154 binding polypeptide that specifically recognizes CD154. The polypeptide according to the present disclosure effectively inhibits the CD154-CD40 interaction without activating platelets, and thus can be effectively used in the prevention or treatment of various T cell-mediated or antibody-mediated diseases or symptoms, which requires inhibition of the interaction.
Claims16
A CD154 binding polypeptide comprising a HCDR (Complementary Determining Region) 1, 2 and 3 from a immunoglobulin heavy chain variable region (VH);
- and LCDR 1, 2 and 3 from a immunoglobulin light chain variable region (VL),
- wherein the HCDR1 has a sequence set forth in SEQ ID NO:
- 1;
- the HCDR2 has a sequence set forth in SEQ ID NO:
- 2 and the HCDR3 has a sequence set forth in SEQ ID NO:
- 3;
- and the LCDR1 has a sequence set forth in SEQ ID NO:
- 4, the LCDR2 has a sequence set forth in SEQ ID NO:
- 5 and the LCDR3 has a sequence set forth in SEQ ID NO:
- 6.
7 more elements
Dependencies are inferred from the claim text.