Multispecific antibodies that target HIV GP120 and CD3
AssigneeGilead Sciences, Inc.
InventorsDoug Rehder, Matthew R. Schenauer, Heather Stephenson, Nathan D. Thomsen
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Abstract
Multispecific antibodies (e.g., bispecific antibodies) that bind to HIV gp120 and CD3 are disclosed. Also disclosed are methods of using such antibodies to treat or prevent HIV infection.
Claims14
An antibody that binds to gp120, wherein the antibody comprises a heavy chain variable domain (VH) and a light chain variable domain (VL), wherein the VH comprises a VH-CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1, a VH-CDR2 comprising the amino acid sequence of SEQ ID NO:
- 2, a VH-CDR3 comprising the amino acid sequence of SEQ ID NO:
- 3, wherein the VL comprises a VL-CDR1 comprising the amino acid sequence of SEQ ID NO:
- 4, a VL-CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5, and a VL-CDR3 comprising the amino acid sequence of SEQ ID NO:
- 6, and wherein the VL comprises a tyrosine at position 67A (Kabat numbering), a phenylalanine at position 67A (Kabat numbering), a threonine at position 67A (Kabat numbering), or a glycine at position 67 (Kabat numbering).
An antibody fragment that binds to gp120, wherein the antibody fragment comprises a heavy chain variable domain (VH) and a light chain variable domain (VL), wherein the VH comprises a VH-CDR1 comprising the amino acid sequence of SEQ ID NO:
- 1, a VH-CDR2 comprising the amino acid sequence of SEQ ID NO:
- 2, a VH-CDR3 comprising the amino acid sequence of SEQ ID NO:
- 3, wherein the VL comprises a VL-CDR1 comprising the amino acid sequence of SEQ ID NO:
- 4 a VL-CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5, and a VL-CDR3 comprising the amino acid sequence of SEQ ID NO:
- 6, and wherein the VL comprises a tyrosine at position 67A (Kabat numbering), a phenylalanine at position 67A (Kabat numbering), a threonine at position 67A (Kabat numbering), or a glycine at position 67 (Kabat numbering).
Dependencies are inferred from the claim text.