Methods and compositions for treating an alphavirus infection
AssigneeArizona Board of Regents on Behalf of the University of Arizona
InventorsJanko Nikolich-Zugich, Jennifer Uhrlaub
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Abstract
Methods and pharmaceutical compositions for preventing, treating or suppressing symptoms of a disorder associated with an alphavirus infection. In particular, the present invention relates to preventing, treating or suppressing symptoms of a disorder associated with an alphavirus infection through inhibiting the activity and/or expression of Transforming Growth Factor Beta (TGF-β) in a subject suffering from or at risk for suffering from an alphavirus infection.
Claims6
A method of treating Chikungunya virus infection in a subject, comprising administering to the subject an effective amount of an anti-TGF-β antibody that inhibits TGF-β1, TGF-β2, and/or TGF-β3 activity, wherein said antibody is TGF-β antibody clone 1D11.16.8, and wherein the treating results in a decrease in one or more symptoms related to the Chikungunya virus infection.
Dependencies are inferred from the claim text.