Methods of treating diabetes by an adipocyte protein 2 specific antibody
AssigneePresident and Fellows of Harvard College
InventorsGokhan S. Hotamisligil, Haiming Cao
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Abstract
A method of reducing a symptom of a clinical disorder characterized by aberrantly elevated circulating aP2 is carried out by administering to a subject an inhibitor of secreted aP2, secretion of aP2, or a serum aP2 blocking agent. For example, glucose intolerance is reduced following administration of such an inhibitor or agent. Exemplary compositions inhibit cellular secretion of aP2 or bind to circulating aP2, thereby reducing the level or activity of aP2 in blood or serum.
Claims5
A method of treating diabetes in a human in need thereof comprising administering to the human an effective amount of an Adipocyte Protein 2 (aP2)-specific antibody that specifically binds to aP2 in blood or serum, wherein administration of the aP2-specific antibody results in reduced serum aP2 activity or reduced blood glucose levels.
Dependencies are inferred from the claim text.